Reboot the system to initialize the driver sub-layers within Windows 10 64-bit.
By following this guide, you should be able to successfully connect and use your Targus PA088E USB to Serial Adapter with your 64-bit Windows 10 system. If you continue to experience difficulties, please contact Targus customer support for further assistance. targus+pa088e+driver+windows+10+64+bit+link
To make the PA088E work on modern Windows systems, you must bypass the official Targus driver and use the Prolific chipset driver. Reboot the system to initialize the driver sub-layers
The original manufacturer-provided driver file is available in the Targus support archives. The file is named pa088e_v3_0_0.exe , which is version 3.0.0 of the driver software, dated back to around February 2008. To make the PA088E work on modern Windows
https://www.targus.com/us/support/product/pa088e
: A version of the PA088E software (v3.0.0) is sometimes hosted on Targus.bg . Manual Installation Steps for Windows 10 64-bit
Right-click the Start button and select Device Manager .